Some Metal-Antimalarial Drug Complexes: Synthesis, Characterization and their Effect Against Malaria Parasites

Abstract

A series of metal complexes of Sulfadoxine-Pyrimethamine (SP) have been synthesized and characterized. The crystal structures have been determined by spectroscopic techniques using Infra Red (l R), and UV – visible spectrophotometer along side physical and micro analytical methods .The prymethamine ligand functions as a bidentate donors through (C-CI) and (N-H) while sulfadoxine through (N-H) and O=S=O making it a chelate compound in 1:2 stoichiometry resulting in octahedral and tetrahedral geometry compounds. The standard drug (chloroquine), parent drug (Primethamine-sulfadoxine) and the complexes were screened against malaria parasites (Plasmodium beighei. NK65 ) for their antimalarial activity using in-vivo method with inhibition level of 91.03%, 93.10% , and 95.17%, 100% respectively. The antimalarial activity of Fe-complex was found to have highest therapeutic value (potency), among the chemotherapeutic agents compared.