Efficacy of Magnesium Chloride Supplementation and Diminazene Aceturate in Rats Inoculated with Trypanosoma Brucei
Keywords:
MgCl2, Diminazene aceturate, Trypanosoma, blood, Parasitaemia
Abstract
The effect of Mgcl2 and Diminazene aceturate in experimental Trypansoma brucei infected rats was investigated. Infection with the parasite caused a progressive increase in parasitaemia which resulted in a significant (P<0.05) decrease in packed cell volume, Red blood cell count and white blood cell count in the infected not treated (group F), the positive control and other groups C,D,E, and G respectively. The treated groups C,D,E and G improved remarkably, but were not clear of the parasites, most especially group D, which was given subtherapeutic dose of diminazene aceturate and supplemented MgCl2 orally at 100 mg/kg per os. This prolonged the life of the rats to up to 27 days. The combination of MgCl2 and diminazene reduced the severity of trypanosome infection and hence alleviated the anaemia and leukopenia.
References
Ajagbonna, O.P., Olaniyi M.O. 1991. Combination therapy of diminazene aceturate and nonsteroidal anti inflammatory drugs on trypanosomosis infection in mice. In J.K. Joseph; B. Awosanyi and Attey (eds) proceedings of the 26th Nigerian Society of Animal Production Conference in Ilorin, Pg 366-367.
Ajagbonna, O.P., Onyeyili, P.A. 2003. Effect of aqueous extract of Allium sativum (Garlic) on haematological and biochemical parameters in rabbits infected with Trypanosoma brucei Proc. 8th Ann. Conf. Anim. Soci. Ass. Of Nig. (ASAN) Sep. 16th-18th Minna.
Ajagbonna, O.P., Biobaku, K.T. Adeneye, A.A., Igbokwe, V., Mojminiyi, F.B.O., Ameh, I.G. 2005. Effects of the combination of Diminazene aceturate and Khaya senegalensis bark extract in Trypanosoma brucei infection of rats. Bulletin of Science Association of Nigeria, Vol. 26: PP 606-613.
Delbet, P.R. 1992. Supplement to the A.t of getting well. Magnesium chloride-Hexahydrale therapy. Aka the Arthritic thrust of America for medical information purposes P. 992.
Egbe-Nwiyi, T.N.C., Nwaosu, S.C., Tsuya, R.D. 2003. Effect of high oral Magnesium Chloride supplementation in the Pathogenicity of Trypanosoma brucei and T. congolense infection in rats. Tropical Veterinarian. Vol. 21: (3) 153-159.
Egbe-Nwiyi, T.N.C., Aliyu, M.M., Igbokwe, I.O. 2004. Effects of trypanosome brucei and T. congolense infection in rats. Sahel Journal of Veterinary Science Vol.3 PP. 39-43.
Ezeokonkwo, R.C., Okoro, F.G., Ezeh, I.O. 2007. The efficacy of increasing doses samorenil in the treatment of Trypanosoma brucei infected albino rats Nigerian Veterinary journal Vol. 28 (2) 24-32.
Igbokwe, I.O. 1994. Increase Susceptibility of erythrocytes to in Vitro peroxidation in Acute Trypanosoma brucei infection of mice. Vet. Parasitol 55:279-286.
Kabayo, J.P. 2002. Aiming to eliminate tse tse from Africa Trends. Parasitol 18: 473-475 (1989).
Kaneko, J.J. 1989. Clinical biochemistry of domestic animal. (4th Edition Academic Press Inc. America) PP. 196-206.
Mikail, H.G., Ajagbonna, O.P., Muhammed B.Y., Onyeyili, P.A. 2002. Garlic a natural agent for treatment of trypanosomosis proceedings of the 39th NVMA conference, Sokoto 2002.
Onyiah, J.A. 1997. African animal trypanosomasis: An overview of the current statues in Nigeria. Trop. Vet. 15:111-116.
Onyeyili, P.A., Eqwu., G.O.I. 1995. Chemotherapy of African trypanosomiasis: a historical perspective protozoological abstracts Vol. 19 (5): PP 229-240.
Radostitis, O.M., Gay, C.C., Blood, D.C., Hinchcliff, K.W. 2003. Diseases of Cattle, Sheep, Pig, Goats and Horses (9th ed Britain) PP. 1330-1334.
Schalm, O.W.; Jain, N.C. Carrol, E.J. 1975. Veterinary Haematology. (3rd edition Lea and Febiger. PhiladeIphia,). PP. 20-280.
Truc, P. 2003. About Trypanosoma brucei gambiense, the causative agent of the chronic form of Human African trypanosomiasis: some findings and proposals. African J. Biotech. 2 (12): 657-661.
Waisawa, C., Olacho-Mukani, E., Katunguka Rwakishaya, E. 2003. Domestic animals as reservoirs for sleeping sickness in free endemic foci in South-Eastern Uganda. Ann. Trop. Med. Parasitol. 97:149-155.
WHO. 1998. Control and Surveillance of Afican trypanosomiasis World health organization Technical report series No. 881 WHO, Geneva, Switzerland.
WHO. 2005. Control and surveillance of African trypanosomiasis Technical Report series 881, Geneva, PP. 1-113.
Ajagbonna, O.P., Onyeyili, P.A. 2003. Effect of aqueous extract of Allium sativum (Garlic) on haematological and biochemical parameters in rabbits infected with Trypanosoma brucei Proc. 8th Ann. Conf. Anim. Soci. Ass. Of Nig. (ASAN) Sep. 16th-18th Minna.
Ajagbonna, O.P., Biobaku, K.T. Adeneye, A.A., Igbokwe, V., Mojminiyi, F.B.O., Ameh, I.G. 2005. Effects of the combination of Diminazene aceturate and Khaya senegalensis bark extract in Trypanosoma brucei infection of rats. Bulletin of Science Association of Nigeria, Vol. 26: PP 606-613.
Delbet, P.R. 1992. Supplement to the A.t of getting well. Magnesium chloride-Hexahydrale therapy. Aka the Arthritic thrust of America for medical information purposes P. 992.
Egbe-Nwiyi, T.N.C., Nwaosu, S.C., Tsuya, R.D. 2003. Effect of high oral Magnesium Chloride supplementation in the Pathogenicity of Trypanosoma brucei and T. congolense infection in rats. Tropical Veterinarian. Vol. 21: (3) 153-159.
Egbe-Nwiyi, T.N.C., Aliyu, M.M., Igbokwe, I.O. 2004. Effects of trypanosome brucei and T. congolense infection in rats. Sahel Journal of Veterinary Science Vol.3 PP. 39-43.
Ezeokonkwo, R.C., Okoro, F.G., Ezeh, I.O. 2007. The efficacy of increasing doses samorenil in the treatment of Trypanosoma brucei infected albino rats Nigerian Veterinary journal Vol. 28 (2) 24-32.
Igbokwe, I.O. 1994. Increase Susceptibility of erythrocytes to in Vitro peroxidation in Acute Trypanosoma brucei infection of mice. Vet. Parasitol 55:279-286.
Kabayo, J.P. 2002. Aiming to eliminate tse tse from Africa Trends. Parasitol 18: 473-475 (1989).
Kaneko, J.J. 1989. Clinical biochemistry of domestic animal. (4th Edition Academic Press Inc. America) PP. 196-206.
Mikail, H.G., Ajagbonna, O.P., Muhammed B.Y., Onyeyili, P.A. 2002. Garlic a natural agent for treatment of trypanosomosis proceedings of the 39th NVMA conference, Sokoto 2002.
Onyiah, J.A. 1997. African animal trypanosomasis: An overview of the current statues in Nigeria. Trop. Vet. 15:111-116.
Onyeyili, P.A., Eqwu., G.O.I. 1995. Chemotherapy of African trypanosomiasis: a historical perspective protozoological abstracts Vol. 19 (5): PP 229-240.
Radostitis, O.M., Gay, C.C., Blood, D.C., Hinchcliff, K.W. 2003. Diseases of Cattle, Sheep, Pig, Goats and Horses (9th ed Britain) PP. 1330-1334.
Schalm, O.W.; Jain, N.C. Carrol, E.J. 1975. Veterinary Haematology. (3rd edition Lea and Febiger. PhiladeIphia,). PP. 20-280.
Truc, P. 2003. About Trypanosoma brucei gambiense, the causative agent of the chronic form of Human African trypanosomiasis: some findings and proposals. African J. Biotech. 2 (12): 657-661.
Waisawa, C., Olacho-Mukani, E., Katunguka Rwakishaya, E. 2003. Domestic animals as reservoirs for sleeping sickness in free endemic foci in South-Eastern Uganda. Ann. Trop. Med. Parasitol. 97:149-155.
WHO. 1998. Control and Surveillance of Afican trypanosomiasis World health organization Technical report series No. 881 WHO, Geneva, Switzerland.
WHO. 2005. Control and surveillance of African trypanosomiasis Technical Report series 881, Geneva, PP. 1-113.
Issue
Section
Articles
